An open-source, trainable reproduction of AlphaFold 3 (AF3) for biomolecular structure prediction. Protenix is designed to predict the 3D structures of complex systems containing proteins, DNA, RNA, small molecule ligands, and ions, achieving state-of-the-art accuracy under the Apache 2.0 license.

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GitHub Repository

sciencebiologyopen-weight

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Notes

Protenix-v1 technical report posted February 9, 2026.